Assessing Learning-Centered Leadership: Connections to Research, Professional Standards, and Current Practices

Describes an assessment model designed to evaluate school leaders' performance. Unlike existing tools, this new system will assess both individuals and teams, and focuses specifically on instructional leadership and behaviors that improve learning

Defining, Developing, and Using Curriculum Indicators

We begin with a brief review of the lessons learned in the Reform Up Close study, a Consortium for Policy Research in Education (CPRE) project funded by the National Science Foundation, then discuss the central issues involved in defining and measuring curriculum indicators, while noting how our approach has developed over the past 10 years (1992-2002). This is followed by a discussion about using curriculum indicators in school improvement, program evaluation, and informing policy decisions

An Anti-hTNF-α Variable New Antigen Receptor Format Demonstrates Superior in vivo Preclinical Efficacy to Humira® in a Transgenic Mouse Autoimmune Polyarthritis Disease Model

Funding The Biotechnology and Biological Sciences Research Council (BB/K010905/1), Scottish Enterprise (VNAR_001 (2012), Innovate UK (102865). Acknowledgments The authors wish to acknowledge the funding support for this work from Scottish Enterprise (SE), the Biotechnology and Biological Sciences Research Council (BBSRC), and Innovate UK.Peer reviewedPublisher PD

In Vitro Maturation of a Humanized Shark VNAR Domain to Improve Its Biophysical Properties to Facilitate Clinical Development

Acknowledgments: The authors would like to acknowledge the funding support for this work from Scottish Enterprise [VNAR_001(2012)] and the Biotechnology and Biological Sciences Research Council (BB/K010905/1).Peer reviewedPublisher PD

Defining the complementarities between antibodies and haptens to refine our understanding and aid the prediction of a successful binding interaction

Acknowledgments The authors would like to thank the Scottish Universities Life Sciences Alliance (SULSA) for their support.Peer reviewedPublisher PD

Inverse Compton Emission from Galactic Supernova Remnants: Effect of the Interstellar Radiation Field

The evidence for particle acceleration in supernova shells comes from electrons whose synchrotron emission is observed in radio and X-rays. Recent observations by the HESS instrument reveal that supernova remnants also emit TeV gamma-rays; long awaited experimental evidence that supernova remnants can accelerate cosmic rays up to the ``knee'' energies. Still, uncertainty exists whether these gamma-rays are produced by electrons via inverse Compton scattering or by protons via neutral pion decay. The multi-wavelength spectra of supernova remnants can be fitted with both mechanisms, although a preference is often given to neutral pion decay due to the spectral shape at very high energies. A recent study of the interstellar radiation field indicates that its energy density, especially in the inner Galaxy, is higher than previously thought. In this paper we evaluate the effect of the interstellar radiation field on the inverse Compton emission of electrons accelerated in a supernova remnant located at different distances from the Galactic Centre. We show that contribution of optical and infra-red photons to the inverse Compton emission may exceed the contribution of cosmic microwave background and in some cases broaden the resulted gamma-ray spectrum. Additionally, we show that if a supernova remnant is located close to the Galactic Centre its gamma-ray spectrum will exhibit a ``universal'' cutoff at very high energies due to the Klein-Nishina effect and not due to the cut-off of the electron spectrum. As an example, we apply our calculations to the supernova remnants RX J1713.7-3946 and G0.9+0.1 recently observed by HESS.Comment: 4 pages, 4 figures. Uses emulateapj.cls. Accepted by ApJ

Upgrading High School Math: A Look at Three Transition Courses

This issue of CPRE Policy Briefs focuses on the nature of instruction in transition math courses, the consequences of student placement in the new transition courses, and the linkages among course type, course content, and student achievement. The findings presented here are based on both qualitative and quantitative data gathered from seven high school across four districts in two states. We studied transition math courses in seven high schools in San Diego and San Francisco in California and in Buffalo and Rochester in New York. We chose schools that had high percentages of minority and low-income students, because the problem of dead-end classes for low-achieving students is most sever in such schools. The transition math courses were initiated as early as 10 years ago in Rochester, New York schools, and 3 to 5 years ago in California schools

Novel, Anti-hTNF-α Variable New Antigen Receptor Formats with Enhanced Neutralising Potency and Multifunctionality, Generated for Therapeutic Development

ACKNOWLEDGMENTS The authors wish to acknowledge the funding support for this work from MSD/Scottish Universities Life Sciences Alliance (SULSA), Scottish Enterprise, the Biotechnology and Biological Sciences Research Council (BBSRC), and the University of Aberdeen. FUNDING Grateful for support from Biotechnology and Biological Sciences Research Council (BB/K010905/1), Scottish Enterprise [VNAR_001 (2012)], Scottish Universities Life Sciences Alliance/ MSD (MSD01_A_Porter-Teismann), and the College of Life Sciences and Medicine, University of Aberdeen (Fee bursary to OU).Peer reviewedPublisher PD

A p34cdc2 survival checkpoint in cancer

AbstractA checkpoint surveying the entry into mitosis responds to defects in spindle microtubule assembly/stability. This has been used to trigger apoptosis in cancer cells, but how the spindle checkpoint couples to the cell survival machinery has remained elusive. Here, we report that microtubule stabilization engenders a survival pathway that depends on elevated activity of p34cdc2 kinase and increased expression of the apoptosis inhibitor and mitotic regulator, survivin. Pharmacologic, genetic, or molecular ablation of p34cdc2 kinase after microtubule stabilization resulted in massive apoptosis independent of p53, suppression of tumor growth, and indefinite survival without toxicity in mice. By ablating this survival checkpoint, inhibitors of p34cdc2 kinase could safely improve the efficacy of microtubule-stabilizing agents used to treat common cancers

Targeting liver myofibroblasts: a novel approach in anti-fibrogenic therapy

Chronic liver disease results in a liver-scarring response termed fibrosis. Excessive scarring leads to cirrhosis, which is associated with high morbidity and mortality. The only treatment for liver cirrhosis is liver transplantation; therefore, much attention has been directed toward therapies that will slow or reverse fibrosis. Although anti-fibrogenic therapies have been shown to be effective in experimental animal models, licensed therapies have yet to emerge. A potential problem for any anti-fibrogenic therapy in the liver is the existence of the body’s major drug metabolising cell (the hepatocyte) adjacent to the primary fibrosis-causing cell, the myofibroblast. This article reviews the development of a human recombinant single-chain antibody (scAb) that binds to the surface of myofibroblasts. This antibody binds specifically to myofibroblasts in fibrotic mouse livers. When conjugated with a compound that stimulates myofibroblast apoptosis, the antibody directs the specific apoptosis of myofibroblasts with greater specificity and efficacy than the free compound. The antibody also reduces the adverse effect of liver macrophage apoptosis and—in contrast to the free compound—reversed fibrosis in the sustained injury model used. These data suggest that specifically stimulating the apoptosis of liver myofibroblasts using a targeting antibody has potential in the treatment of liver fibrosis